What is Viagra?

Viagra helps to calm muscle detected in the blood vessels walls and enhances blood flow to specific parts of the body. The major purpose of this medication is to manage impotence (erectile dysfunction) in males.

SIldenafil’s another brand version is known as the name of Revatio, which helps to manage pulmonary arterial hypertension and increase the capacity of exercise in males and females. This medication blocks the activity of an enzyme (PDE5), and this is how it works.

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Mechanism of action of Viagra

Release of NO (Nitric Oxide) and sexual stimulation- Endothelial cells and nerve impulses presented in the penis liberate nitric oxide upon sexual arousal.

Production of cGMP- Nitric Oxide then assists in activating the guanylate cyclase enzyme, which enhances the cGMP production.

Smooth relaxation of muscle- cGMP functions as a second messenger, causing the muscles presented in the walls of the corpus cavernosum and helicine arteries to dilate and calm. It leads to enhanced flow of the blood into the penile tissue.

Erection and blood engorgement- The enhanced inflow of the blood causes the enormous spaces presented in the penis to engorge with blood. Additionally, the venules are compressed by the growing tissue, which traps the blood and produces a stiff erection.

Function of PDE5- The PDE5 enzyme converts cGMP into its inactive form, guanosine monophosphate (GMP), which naturally reverses the erection process.

Action of Sildenafil- Sildenafil functions by blocking the action of the enzyme (PDE5), which helps to break down cGMP into its inactive form GMP.

In response to ongoing sexual stimulation, this results in increased and prolonged amounts of cGMP in the corpus cavernosum, which in turn promotes better blood flow and more prolonged smooth muscle relaxation, making it easier to establish and sustain an erection.

Active and Inactive ingredients of Viagra

Active ingredients- Sildenafil citrate

Inactive ingredients

• Anhydrous dibasic calcium phosphate
• Croscarmellose sodium
• Microcrystalline cellulose
• Hypromellose
• Magnesium stearate
• Lactose monohydrate
• Titanium dioxide
• Triacetin
• Coloring agent (FD & C Blue No. 2 aluminum lake)

Before buying Viagra online, ensure that you don’t have any allergy to any of its ingredients.

History And FDA Status of Viagra

Major motive- Sildenafil was developed by Pfizer in 1989 to manage the symptoms of hypertension and angina.

Discovery of ED (erectile dysfunction)- According to the research, those who participated in clinical trials noticed increased erectile function as an adverse reaction.

Approval and patent- Pfizer sought approval from food and drug administration (FDA) and filed a patent in 1994 for impotence (ED) based on its new discovery.

Approval from FDA- After a priority review, Viagra got approval from food and drug administration (FDA) on March 27, 1998. This medication was the initial medication of its kind, a PDE5 inhibitor, to be approved for this usage.

Cultural impact- The medication had a major and immediate effect, mainly because of consumer advertising, which helps to prompt males to discuss sexual health with their healthcare experts.

Subsequent approvals- The food and drug administration has since approved this medication to manage PAH (pulmonary arterial hypertension) under the brand version Revatio, which functions by calming blood vessels in the lungs.

Colors, imprints, and other details of Viagra

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Warnings and precautions while using Viagra

Taking other medications along with Viagra can be harmful and show dangerous drug interaction. Let your healthcare expert know about all your current drugs, mainly nitrates and riociguat.

Avoid the consumption of this medication if you are already taking nitrates for heart issues or chest discomfort, including isosorbite mononitrate, nitroglycerin, isosorbide dinitrate, and a few recreational medications. If you take sildenafil with a nitrate, it may cause severe and sudden reduction in BP.

Contact your healthcare expert or seek urgent medical help if your erection is unbearable or stays more than 4 hours. A priapism (prolonged erection) might harm the penis. Stop taking this medication and get urgent medical attention if you have sudden vision loss.

Before using Viagra

Avoid taking Viagra if you have an allergy to sildenafil or;

• If you take other drugs to manage pulmonary arterial hypertension, such as Adempas.
• If you already use nitrates

This medication may cause reduction in blood flow to the optic nerve of the eye, and causes sudden vision loss. This medication is not expected to trouble an unborn baby. Let your healthcare expert if you are planning to have a baby or become pregnant.

You must follow these instructions to get the best desired outcomes after you buy Viagra online.

Potential side effects of Viagra

Get urgent medical attention if you have symptoms of an allergic reaction to this medication such as difficulty breathing, hives, and swelling of your body parts. Stop using this drug and get urgent medical attention if you have-

Heart attack symptoms- Chest discomfort or pressure, sweating, nausea, and discomfort spreading to your shoulder or jaw

• Sudden vision loss or changes in vision
• Erection is unbearable or stays more than 4 hours

Let your healthcare expert immediately if you have

• Sudden hearing loss, or ringing in your ears
• Irregular heartbeat
• Shortness of breath
• Swelling in your ankles, hands, or feet
• Convulsions

Common side effects of this medication may include

Dosing details of Viagra

For more users, the recommended dosage is 50 mg used, as required, almost an hour before participating in sexual activity. However, this medication might be used anywhere from half an hour before sexual activity. The highest recommended dosing frequency is once daily.

Based on toleration and effectiveness, the dosage might be increased to a highest recommended dosage of 100 mg or reduction to 25 mg.

Dosage adjustments in particular situations

Since Viagra has been demonstrated to intensify the hypotensive effects of nitrates, it is not recommended to administer it to patients who utilize nitric oxide donors, such as organic nitrates or organic nitrites in any form.

When VIAGRA and an alpha-blocker are taken together, patients should be stable on alpha-blocker therapy before starting VIAGRA treatment, and VIAGRA should be started at 25 mg.

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Conclusion

Viagra can be an effective tool for those suffering from ED (erectile dysfunction) if taken as prescribed. Abruptly stopping this medication after long-term usage can be harmful and may cause unwanted withdrawal symptoms.

Viagra should not recommend this drug to anyone below eighteen years without any clinical advice. We recommend you to take Viagra under the healthcare expert of an experienced healthcare expert to get the best possible results.

FAQs (Frequently Asked Questions)

What are the common side effects of Viagra?

The common side effects of Viagra may include flushing, stomach upset, headache, muscle discomfort, nasal congestion, and vision changes.

Is this medication safe for everyone to take?

This medication is safe for most individuals, but it doesn’t mean that it is suitable for everyone. People with specific medical conditions, mainly heart issues, or those using particular drugs, should not use it. Before buying Viagra, you must consult a healthcare provider.

Can I take Viagra after having meals?

Yeah, you may consume this medication with or without having meals. However, a high-calory meal might cause the drug to take longer to begin working.

How much time does it take for Viagra to work?

Viagra generally begins working within 30-60 minutes, though it might function as fast as 12 minutes in a few men.